PMID:2863818
| Citation |
Abraham, JM, Freitag, CS, Clements, JR and Eisenstein, BI (1985) An invertible element of DNA controls phase variation of type 1 fimbriae of Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 82:5724-7 |
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| Abstract |
The expression of type 1 fimbriae (pili) of Escherichia coli is turned on and off at the transcriptional level at a high frequency (10(-3) per cell per generation) in a process termed phase variation. Using Southern blot and DNA sequence analysis, we have detected a genomic rearrangement in the switch region immediately upstream of the fimbrial structural gene. This rearrangement involves an invertible 314-base-pair segment of DNA whose alternating orientation apparently results in the on-and-off activation of a promoter that determines the state of fimbrial expression. |
| Links | |
| Keywords |
Base Sequence; Chromosome Inversion; DNA, Bacterial/genetics; Escherichia coli/genetics; Fimbriae, Bacterial; Gene Expression Regulation; Genes; Genes, Regulator; Genetic Linkage; Promoter Regions, Genetic; Recombination, Genetic |
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