PMID:2693900

Citation	Poulsen, LK, Larsen, NW, Molin, S and Andersson, P (1989) A family of genes encoding a cell-killing function may be conserved in all gram-negative bacteria. Mol. Microbiol. 3:1463-72
Abstract	The relF gene in Escherichia coli is related to the hok gene on plasmid R1. Both genes encode small proteins which, when overexpressed in E. coli lead to collapse of the membrane potential and cell death. A third gene, designated gef, which encodes a homologous cell-toxic protein, has been isolated from E. coli DNA. Both gef and relF are transcribed in E. coli and subject to post-transcriptional regulation which, in the case of gef, is coupled to translation of a leader sequence. The finding of homologous sequences in such distantly related bacteria as Agrobacterium and Rhizobium species suggests an important physiological role.
Links	PubMed
Keywords	Amino Acid Sequence; Base Sequence; Chromosome Mapping; Escherichia coli/genetics; Gene Expression Regulation, Bacterial; Genes, Bacterial; Gram-Negative Bacteria/genetics; Molecular Sequence Data; Mutation; R Factors; RNA Processing, Post-Transcriptional; Sequence Homology, Nucleic Acid
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