PMID:2678630
| Citation |
Creighton, TE and Darby, NJ (1989) Functional evolutionary divergence of proteolytic enzymes and their inhibitors. Trends Biochem. Sci. 14:319-24 |
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| Abstract |
The amino acid residues of protease inhibitors that interact directly with proteases are hypervariable, suggesting recent positive evolutionary selection for functional differences between them. A similar hypervariability is apparent in some proteases, which may be co-evolving with the inhibitors. |
| Links | |
| Keywords |
Animals; Binding Sites; Biological Evolution; Genes; Genetic Variation; Humans; Peptide Hydrolases/genetics; Peptide Hydrolases/metabolism; Protease Inhibitors/metabolism; Protein Conformation; Selection, Genetic |
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