PMID:2677754

Citation	Phillips, SE, Manfield, I, Parsons, I, Davidson, BE, Rafferty, JB, Somers, WS, Margarita, D, Cohen, GN, Saint-Girons, I and Stockley, PG (1989) Cooperative tandem binding of met repressor of Escherichia coli. Nature 341:711-5
Abstract	We present biochemical and genetic data to support the hypothesis that the Escherichia coli met repressor, MetJ, binds to synthetic and natural operator sequences in tandem arrays such that repression depends not only on the affinity of the DNA-protein interaction, but also on protein-protein contacts along the tandem array. This represents a novel form of regulatory switch. Furthermore, there seems to be homology between the organization of the met and trp operators.
Links	PubMed Online version:10.1038/341711a0
Keywords	Apoproteins/biosynthesis; Apoproteins/metabolism; Bacterial Proteins/metabolism; Base Sequence; DNA, Bacterial/metabolism; Escherichia coli/metabolism; Escherichia coli Proteins; Genes, Bacterial; Models, Molecular; Molecular Sequence Data; Operator Regions, Genetic; Regulatory Sequences, Nucleic Acid; Repetitive Sequences, Nucleic Acid; Repressor Proteins/biosynthesis; Repressor Proteins/metabolism; Transcription Factors/metabolism; Tryptophan/metabolism
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