PMID:2608483

Citation	*Katahira, M, Sugeta, H and Kyogoku, Y' (1989) A new model for DNA bending on the basis of gradual compression of the minor groove from 5' to 3' along the oligo(dA) tract.* Nucleic Acids Symp. Ser. '**:69-70
Abstract	The conformations of double stranded d(GGAAATTTCC) x 2, d(GGTTTAAACC) x 2, d(CGCAAAAAAGCG).d(CGCTTTTTTGCG) and d(GCATTTTGAAACG).d(CGTTTCAAAATGC) have been studied by means of NMR spectroscopy. Analyses of cross peaks in NOESY spectra between H2 of an adenine and H1' of the deoxyribose in the 3'-neighbouring residue on the complementary strand revealed that the minor groove of the oligo(dA) tract is compressed gradually from 5' to 3' along the tract in four oligonucleotides. A new model is proposed as to DNA bending based on the evidence of gradual compression of the minor groove. This model can explain why d(GGAAATTTCC) n x 2 and d(GAAAATTTTC) n x 2 are bent, and d(GGTTTAAACC) n x 2 and d(GTTTTAAAAC) n x 2 are not bent. The bending of d(AjN10-j) n x 2 sequences can also be explained.
Links	PubMed
Keywords	DNA; Magnetic Resonance Spectroscopy; Models, Chemical; Nucleic Acid Conformation; Oligodeoxyribonucleotides
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