PMID:2544886
| Citation |
Farr, SB, Arnosti, DN, Chamberlin, MJ and Ames, BN (1989) An apaH mutation causes AppppA to accumulate and affects motility and catabolite repression in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 86:5010-4 |
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| Abstract |
apaH- mutants lack the hydrolase responsible for degradation of AppppN dinucleotides in Escherichia coli and show a greater than or equal to 16-fold increase in AppppA under nonstress conditions. These mutants lack detectable activity of sigma F, a factor required for transcription of motility and chemotaxis genes. Expression of the flbB/flaI operon, thought to encode sigma F, is decreased in apaH- mutants, and there appears to be a general decrease in expression of genes regulated by cAMP-binding protein and cAMP as well. |
| Links | |
| Keywords |
Cell Movement; DNA Transposable Elements; Dinucleoside Phosphates/metabolism; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli/physiology; Flagellin/genetics; Galactokinase/genetics; Galactokinase/metabolism; Genes; Genes, Bacterial; Genotype; Hydrolases/genetics; Mutation; Nucleotides/metabolism; Transcription, Genetic; beta-Galactosidase/genetics; beta-Galactosidase/metabolism |
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