PMID:2542299
| Citation |
Metzger, S, Sarubbi, E, Glaser, G and Cashel, M (1989) Protein sequences encoded by the relA and the spoT genes of Escherichia coli are interrelated. J. Biol. Chem. 264:9122-5 |
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| Abstract |
relA and spoT are designations for two unlinked Escherichia coli genes whose products function in the synthesis and degradation of guanosine 3',5'-bispyrophosphate during the stringent regulatory response to amino acid deprivation. The RelA protein catalyzes an ATP:GTP 3'-pyrophosphoryl group transfer reaction, and the SpoT protein has a guanosine 3',5'-bispyrophosphate 3'-pyrophosphohydrolyase activity. Both genes have been sequenced recently; the relA gene produces an 84-kDa protein, and the spoT gene is deduced to encode a 79-kDa protein. We report here that the protein sequences of the relA and spoT genes are extensively interrelated. |
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| Keywords |
Amino Acid Sequence; Bacterial Proteins/genetics; Bacterial Proteins/isolation & purification; Base Sequence; Codon/analysis; Escherichia coli/enzymology; Escherichia coli/genetics; Escherichia coli/metabolism; Genes, Bacterial; Guanine Nucleotides/genetics; Guanosine Tetraphosphate/genetics; Guanosine Tetraphosphate/metabolism; Molecular Sequence Data; Sequence Homology, Nucleic Acid |
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