PMID:24580753

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Citation

Krisko, A, Copic, T, Gabaldón, T, Lehner, B and Supek, F (2014) Inferring gene function from evolutionary change in signatures of translation efficiency. Genome Biol. 15:R44

Abstract

The genetic code is redundant, meaning that most amino acids can be encoded by more than one codon. Highly expressed genes tend to use optimal codons to increase the accuracy and speed of translation. Thus, codon usage biases provide a signature of the relative expression levels of genes, which can, uniquely, be quantified across the domains of life.

Links

PubMed PMC4054840 Online version:10.1186/gb-2014-15-3-r44

Keywords

Adaptation, Physiological; Archaea/genetics; Bacteria/genetics; Evolution, Molecular; Genes, Archaeal; Genes, Bacterial; Genetic Code; Protein Biosynthesis; Transcriptome

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