PMID:24123841
| Citation |
Haase, I, Sarge, S, Illarionov, B, Laudert, D, Hohmann, HP, Bacher, A and Fischer, M (2013) Enzymes from the haloacid dehalogenase (HAD) superfamily catalyse the elusive dephosphorylation step of riboflavin biosynthesis. Chembiochem 14:2272-5 |
|---|---|
| Abstract |
The missing link: Studies on the biosynthesis of riboflavin have failed to characterise dephosphorylation of the intermediate 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate. We show that this reaction can be catalysed in Escherichia coli by YigB and YbjI and in plant chloroplasts by AtcpFHy1, which are members of the haloacid dehalogenase superfamily. |
| Links |
PubMed Online version:10.1002/cbic.201300544 |
| Keywords |
Biocatalysis; Escherichia coli/enzymology; Hydrolases/metabolism; Molecular Conformation; Phosphorylation; Riboflavin/biosynthesis; Riboflavin/chemistry |
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