PMID:22958895
| Citation |
Zhang, Y and Lin, K (2012) A phylogenomic analysis of Escherichia coli / Shigella group: implications of genomic features associated with pathogenicity and ecological adaptation. BMC Evol. Biol. 12:174 |
|---|---|
| Abstract |
The Escherichia coli species contains a variety of commensal and pathogenic strains, and its intraspecific diversity is extraordinarily high. With the availability of an increasing number of E. coli strain genomes, a more comprehensive concept of their evolutionary history and ecological adaptation can be developed using phylogenomic analyses. In this study, we constructed two types of whole-genome phylogenies based on 34 E. coli strains using collinear genomic segments. The first phylogeny was based on the concatenated collinear regions shared by all of the studied genomes, and the second phylogeny was based on the variable collinear regions that are absent from at least one genome. Intuitively, the first phylogeny is likely to reveal the lineal evolutionary history among these strains (i.e., an evolutionary phylogeny), whereas the latter phylogeny is likely to reflect the whole-genome similarities of extant strains (i.e., a similarity phylogeny). |
| Links |
PubMed PMC3444427 Online version:10.1186/1471-2148-12-174 |
| Keywords |
Adaptation, Biological; Base Sequence; Biological Evolution; Escherichia coli/classification; Escherichia coli/genetics; Escherichia coli/pathogenicity; Genome, Bacterial; Genomics; Molecular Sequence Data; Phylogeny; Shigella/classification; Shigella/genetics; Shigella/pathogenicity |
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