PMID:227838
| Citation |
Alderman, EM, Dills, SS, Melton, T and Dobrogosz, WJ (1979) Cyclic adenosine 3',5'-monophosphate regulation of the bacteriophage T6/colicin K receptor in Escherichia coli. J. Bacteriol. 140:369-76 |
|---|---|
| Abstract |
Mutant strains of Escherichia coli unable to synthesize cyclic adenosine 3',5'-monophosphate (cAMP) or the cyclic adenosine monophosphate receptor protein (CRP) were more resistant than wild-type cells to infection by bacteriophage T6. This resistance was found to be associated with the decreased production of specific T6 receptor protein (also the colicin K receptor) located in the outer membrane protein fraction of these cells. Transcription of this particular outer membrane protein was regulated by the cAMP-CRP complex. A novel affinity technique coupled with sodium dodecyl sulfate-polyacrylamide gel electrophoresis was used in these investigations. |
| Links | |
| Keywords |
Bacterial Proteins/biosynthesis; Colicins; Cyclic AMP/physiology; Escherichia coli/metabolism; Mutation; Receptors, Cyclic AMP/physiology; Receptors, Drug/biosynthesis; Receptors, Virus/biosynthesis; Transcription, Genetic |
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