PMID:22558257
| Citation |
Swarts, DC, Mosterd, C, van Passel, MW and Brouns, SJ (2012) CRISPR interference directs strand specific spacer acquisition. PLoS ONE 7:e35888 |
|---|---|
| Abstract |
CRISPR/Cas is a widespread adaptive immune system in prokaryotes. This system integrates short stretches of DNA derived from invading nucleic acids into genomic CRISPR loci, which function as memory of previously encountered invaders. In Escherichia coli, transcripts of these loci are cleaved into small RNAs and utilized by the Cascade complex to bind invader DNA, which is then likely degraded by Cas3 during CRISPR interference. |
| Links |
PubMed PMC3338789 Online version:10.1371/journal.pone.0035888 |
| Keywords |
Antibiosis/genetics; Bacteriophages/genetics; Base Sequence; DNA/genetics; DNA, Bacterial; DNA, Intergenic/genetics; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli/virology; Molecular Sequence Data; Plasmids |
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