PMID:22556256
| Citation |
Schuetz, R, Zamboni, N, Zampieri, M, Heinemann, M and Sauer, U (2012) Multidimensional optimality of microbial metabolism. Science 336:601-4 |
|---|---|
| Abstract |
Although the network topology of metabolism is well known, understanding the principles that govern the distribution of fluxes through metabolism lags behind. Experimentally, these fluxes can be measured by (13)C-flux analysis, and there has been a long-standing interest in understanding this functional network operation from an evolutionary perspective. On the basis of (13)C-determined fluxes from nine bacteria and multi-objective optimization theory, we show that metabolism operates close to the Pareto-optimal surface of a three-dimensional space defined by competing objectives. Consistent with flux data from evolved Escherichia coli, we propose that flux states evolve under the trade-off between two principles: optimality under one given condition and minimal adjustment between conditions. These principles form the forces by which evolution shapes metabolic fluxes in microorganisms' environmental context. |
| Links |
PubMed Online version:10.1126/science.1216882 |
| Keywords |
Adaptation, Physiological; Adenosine Triphosphate/metabolism; Aerobiosis; Algorithms; Bacteria/growth & development; Bacteria/metabolism; Biological Evolution; Biomass; Computer Simulation; Escherichia coli/genetics; Escherichia coli/growth & development; Escherichia coli/metabolism; Glucose/metabolism; Metabolic Networks and Pathways; Models, Biological |
| edit table |
Significance
You can help EcoliWiki by summarizing why this paper is useful
Useful Materials and Methods
You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.
Annotations
<annotationlinks/>
EcoliWiki Links
Add links to pages that link here (e.g. gene, product, method pages)
See also
References
See Help:References for how to manage references in EcoliWiki.