PMID:222740
| Citation |
Swenson, PA (1979) Antipain lethality to Escherichia coli: dependence upon cyclic adenosine 3',5'-monophosphate and its receptor protein. J. Bacteriol. 139:690-3 |
|---|---|
| Abstract |
Antipain kills Escherichia coli K-12 cells in an exponential manner beginning 1 h after its addition. Mutant strains, delta cya and crp, which are unable to synthesize cyclic adenosine 3',5'-monophosphate (cAMP) and the cAMP receptor protein, respectively, are not affected. Addition of cAMP (5 mM) to antipain-treated mutant strains causes killing of delta cya cells, but not crp cells. Thus the lethal effect of antipain is dependent upon cAMP and its receptor protein. |
| Links | |
| Keywords |
Cyclic AMP/physiology; Escherichia coli/drug effects; Escherichia coli/growth & development; Protease Inhibitors/pharmacology; Receptors, Cyclic AMP/physiology |
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