PMID:22152010
| Citation |
Liu, IF, Aedo, S and Tse-Dinh, YC (2011) Resistance to topoisomerase cleavage complex induced lethality in Escherichia coli via titration of transcription regulators PurR and FNR. BMC Microbiol. 11:261 |
|---|---|
| Abstract |
Accumulation of gyrase cleavage complex in Escherichia coli from the action of quinolone antibiotics induces an oxidative damage cell death pathway. The oxidative cell death pathway has also been shown to be involved in the lethality following accumulation of cleavage complex formed by bacterial topoisomerase I with mutations that result in defective DNA religation. |
| Links |
PubMed PMC3266220 Online version:10.1186/1471-2180-11-261 |
| Keywords |
DNA Topoisomerases, Type I/metabolism; Drug Resistance, Bacterial; Escherichia coli/drug effects; Escherichia coli/enzymology; Escherichia coli/genetics; Escherichia coli Proteins; Iron-Sulfur Proteins; Norfloxacin/pharmacology; Oxidative Stress; Quinolones/pharmacology; Repressor Proteins; Transcription Factors/genetics; Yersinia/enzymology; Yersinia/genetics |
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