PMID:2207172

Citation	Brimacombe, R, Gornicki, P, Greuer, B, Mitchell, P, Osswald, M, Rinke-Appel, J, Schüler, D and Stade, K (1990) The three-dimensional structure and function of Escherichia coli ribosomal RNA, as studied by cross-linking techniques. Biochim. Biophys. Acta 1050:8-13
Abstract	A large number of intra-RNA and RNA-protein cross-link sites have been localized within the 23S RNA from E. coli 50 S ribosomal subunits. These sites, together with other data, are sufficient to constrain the secondary structure of the 23 S molecule into a compact three-dimensional shape. Some of the features of this structure are discussed, in particular, those relating to the orientation of tRNA on the 50 S subunit as studied by site-directed cross-linking techniques. A corresponding model for the 16S RNA within the 30 S subunit has already been described, and here a site-directed cross-linking approach is being used to determine the path followed through the subunit by messenger RNA.
Links	PubMed
Keywords	Base Sequence; Cross-Linking Reagents; Escherichia coli/genetics; Models, Structural; Molecular Sequence Data; Nucleic Acid Conformation; RNA, Ribosomal/genetics; RNA, Ribosomal/ultrastructure; RNA, Ribosomal, 23S/genetics; RNA, Ribosomal, 23S/ultrastructure; Ribosomes/metabolism; Ribosomes/ultrastructure
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