PMID:2204157
| Citation |
Kaback, HR, Bibi, E and Roepe, PD (1990) Beta-galactoside transport in E. coli: a functional dissection of lac permease. Trends Biochem. Sci. 15:309-14 |
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| Abstract |
The polytopic membrane protein lac permease harnesses energy from the electrochemical H+ gradient to transport beta-galactosidases against a concentration gradient. Although high-resolution structural information is still lacking, the permease is thought to possess 12 membrane-spanning alpha-helical segments. Various experimental strategies, including site-directed mutagenesis, have been employed to probe the function of this membrane protein at the molecular level. |
| Links | |
| Keywords |
Amino Acid Sequence; Biological Transport; Escherichia coli/enzymology; Escherichia coli/metabolism; Escherichia coli Proteins; Galactosides/metabolism; Glycosides/metabolism; Membrane Transport Proteins/physiology; Molecular Sequence Data; Monosaccharide Transport Proteins; Symporters |
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