PMID:22035052
| Citation |
Skippington, E and Ragan, MA (2011) Within-species lateral genetic transfer and the evolution of transcriptional regulation in Escherichia coli and Shigella. BMC Genomics 12:532 |
|---|---|
| Abstract |
Changes in transcriptional regulation underlie many of the phenotypic differences observed within and between species of bacteria. Lateral genetic transfer (LGT) can significantly impact the transcription factor (TF) genes which drive these transcriptional changes. Although much emphasis has been placed on LGT of intact genes, the units of transfer and recombination do not necessarily correspond to regions delineated by exact gene boundaries. Here we apply phylogenetic and network-based methods to investigate the relationship between units of lateral transfer and recombination within the Escherichia coli - Shigella clade and the topological properties of genes in the E. coli transcriptional regulatory network (TRN). |
| Links |
PubMed PMC3212841 Online version:10.1186/1471-2164-12-532 |
| Keywords |
Biological Evolution; Escherichia coli/classification; Escherichia coli/genetics; Gene Regulatory Networks; Gene Transfer, Horizontal; Phylogeny; Shigella/classification; Shigella/genetics; Transcription Factors/genetics |
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