PMID:2202721
| Citation |
Bieker, KL, Phillips, GJ and Silhavy, TJ (1990) The sec and prl genes of Escherichia coli. J. Bioenerg. Biomembr. 22:291-310 |
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| Abstract |
Two general approaches have been used to define genetically the genes that encode components of the cellular protein export machinery. One of these strategies identifies mutations that confer a conditional-lethal, pleiotropic export defect (sec, secretion). The other identifies dominant suppressors of signal sequence mutations (prl, protein localization). Subsequent characterization reveals that in at least three cases, prlA/secY, prlD/secA, and prlG/secE, both types of mutations are found within the same structural gene. This convergence is satisfying and provides compelling evidence for direct involvement of these gene products in the export process. |
| Links | |
| Keywords |
Bacterial Proteins/genetics; Bacterial Proteins/secretion; Escherichia coli/genetics; Escherichia coli/metabolism; Mutation; Protein Sorting Signals/genetics; Suppression, Genetic |
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