PMID:2201868
| Citation |
Iuchi, S, Matsuda, Z, Fujiwara, T and Lin, EC (1990) The arcB gene of Escherichia coli encodes a sensor-regulator protein for anaerobic repression of the arc modulon. Mol. Microbiol. 4:715-27 |
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| Abstract |
The arcA (dye) and arcB genes of Escherichia coli are responsible for anaerobic repression of target operons and regulons of aerobic function (the arc modulon). The amino acid sequence of ArcA (Dye) indicated that it is the regulator protein of a two-component control system. Here we show that ArcB is a membrane sensor protein on the basis of its deduced amino acid sequence (778 residues), hydropathicity profile, and cellular distribution. On the carboxyl end of the ArcB sequence there is an additional domain showing homology with conserved regions of regulator proteins. Deletion into this domain destroyed ArcB function. ArcB conserved a histidine residue for autophosphorylation of the sensor proteins, and aspartic residues important for the regulator proteins. |
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| Keywords |
Amino Acid Sequence; Anaerobiosis; Bacterial Proteins/genetics; Base Sequence; Chromosome Deletion; Cloning, Molecular; DNA, Bacterial/analysis; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins; Genes, Regulator; Membrane Proteins/genetics; Molecular Sequence Data; Operon; Protein Kinases; Repressor Proteins/genetics; Sequence Homology, Nucleic Acid; Transcription Factors/genetics |
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