PMID:22000509
| Citation |
Haswell, ES, Phillips, R and Rees, DC (2011) Mechanosensitive channels: what can they do and how do they do it? Structure 19:1356-69 |
|---|---|
| Abstract |
While mechanobiological processes employ diverse mechanisms, at their heart are force-induced perturbations in the structure and dynamics of molecules capable of triggering subsequent events. Among the best characterized force-sensing systems are bacterial mechanosensitive channels. These channels reflect an intimate coupling of protein conformation with the mechanics of the surrounding membrane; the membrane serves as an adaptable sensor that responds to an input of applied force and converts it into an output signal, interpreted for the cell by mechanosensitive channels. The cell can exploit this information in a number of ways: ensuring cellular viability in the presence of osmotic stress and perhaps also serving as a signal transducer for membrane tension or other functions. This review focuses on the bacterial mechanosensitive channels of large (MscL) and small (MscS) conductance and their eukaryotic homologs, with an emphasis on the outstanding issues surrounding the function and mechanism of this fascinating class of molecules. |
| Links |
PubMed PMC3203646 Online version:10.1016/j.str.2011.09.005 |
| Keywords |
Arabidopsis/metabolism; Arabidopsis/physiology; Cell Membrane/metabolism; Cell Membrane/physiology; Computational Biology; Escherichia coli/metabolism; Escherichia coli/physiology; Escherichia coli Proteins/metabolism; Eukaryota/metabolism; Eukaryota/physiology; Hydrophobic and Hydrophilic Interactions; Ion Channel Gating/physiology; Ion Channels/metabolism; Mechanotransduction, Cellular; Membrane Proteins/metabolism; Mutagenesis, Site-Directed; Osmotic Pressure; Protein Conformation; Protein Stability |
| edit table |
Significance
You can help EcoliWiki by summarizing why this paper is useful
Useful Materials and Methods
You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.
Annotations
<annotationlinks/>
EcoliWiki Links
Add links to pages that link here (e.g. gene, product, method pages)
See also
References
See Help:References for how to manage references in EcoliWiki.