PMID:21943372
| Citation |
Kandhavelu, M, Mannerström, H, Gupta, A, Häkkinen, A, Lloyd-Price, J, Yli-Harja, O and Ribeiro, AS (2011) In vivo kinetics of transcription initiation of the lar promoter in Escherichia coli. Evidence for a sequential mechanism with two rate-limiting steps. BMC Syst Biol 5:149 |
|---|---|
| Abstract |
In Escherichia coli the mean and cell-to-cell diversity in RNA numbers of different genes vary widely. This is likely due to different kinetics of transcription initiation, a complex process with multiple rate-limiting steps that affect RNA production. |
| Links |
PubMed PMC3191489 Online version:10.1186/1752-0509-5-149 |
| Keywords |
Arabinose/genetics; Arabinose/metabolism; DNA Primers/genetics; Escherichia coli/physiology; Kinetics; Lac Operon/genetics; Models, Biological; Promoter Regions, Genetic/genetics; RNA/biosynthesis; Systems Biology; Transcriptional Activation/physiology |
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