PMID:21880124
| Citation |
Pinske, C and Sawers, G (2011) Iron restriction induces preferential down-regulation of H(2)-consuming over H(2)-evolving reactions during fermentative growth of Escherichia coli. BMC Microbiol. 11:196 |
|---|---|
| Abstract |
Escherichia coli synthesizes three anaerobically inducible [NiFe]-hydrogenases (Hyd). All three enzymes have a [NiFe]-cofactor in the large subunit and each enzyme also has an iron-sulfur-containing small subunit that is required for electron transfer. In order to synthesize functionally active Hyd enzymes iron must be supplied to the maturation pathways for both the large and small subunits. The focus of this study was the analysis of the iron uptake systems required for synthesis of active Hyd-1, Hyd-2 and Hyd-3 during fermentative growth. |
| Links |
PubMed PMC3176205 Online version:10.1186/1471-2180-11-196 |
| Keywords |
Biological Transport; Cation Transport Proteins/genetics; Cation Transport Proteins/metabolism; Down-Regulation; Escherichia coli/enzymology; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Fermentation; Hydrogen/metabolism; Hydrogenase/genetics; Hydrogenase/metabolism; Iron/metabolism; Oxidoreductases/genetics; Oxidoreductases/metabolism |
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