PMID:21856849
| Citation |
Husain, F, Bikhchandani, M and Nikaido, H (2011) Vestibules are part of the substrate path in the multidrug efflux transporter AcrB of Escherichia coli. J. Bacteriol. 193:5847-9 |
|---|---|
| Abstract |
The path of substrates in the multidrug efflux pump AcrB of Escherichia coli was examined by using labeling with a lipophilic substrate mimic, Bodipy FL maleimide. Four (out of eight) residues in the vestibule bound the dye, suggesting its role in substrate transport, whereas only one (out of nine) residue in the central cavity tested positive. |
| Links |
PubMed PMC3187200 Online version:10.1128/JB.05759-11 |
| Keywords |
Amino Acid Motifs; Anti-Bacterial Agents/metabolism; Anti-Bacterial Agents/pharmacology; Binding Sites; Escherichia coli/chemistry; Escherichia coli/drug effects; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins/chemistry; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Molecular Conformation; Multidrug Resistance-Associated Proteins/chemistry; Multidrug Resistance-Associated Proteins/genetics; Multidrug Resistance-Associated Proteins/metabolism; Protein Binding; Protein Structure, Tertiary; Substrate Specificity |
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