PMID:2185473

Citation	Gottesman, S, Squires, C, Pichersky, E, Carrington, M, Hobbs, M, Mattick, JS, Dalrymple, B, Kuramitsu, H, Shiroza, T and Foster, T (1990) Conservation of the regulatory subunit for the Clp ATP-dependent protease in prokaryotes and eukaryotes. Proc. Natl. Acad. Sci. U.S.A. 87:3513-7
Abstract	Bacteria, tomatoes, and trypanosomes all contain genes for a large protein with extensive homology to the regulatory subunit, ClpA, of the ATP-dependent protease of Escherichia coli, Clp. All members of the family have between 756 and 926 amino acids and contain two large regions, of 233 and 192 amino acids, each containing consensus sequences for nucleotide binding. Within these regions there is at least 85% similarity between the most distant members of the family. The high degree of similarity among the ClpA-like proteins suggests that Clp-like proteases are likely to be important participants in energy-dependent proteolysis in prokaryotic and eukaryotic cells.
Links	PubMed PMC53931
Keywords	ATP-Dependent Proteases; Amino Acid Sequence; Animals; Bacteria/enzymology; Bacteria/genetics; Escherichia coli/enzymology; Escherichia coli/genetics; Heat-Shock Proteins; Molecular Sequence Data; Plants/enzymology; Plants/genetics; Sequence Homology, Nucleic Acid; Serine Endopeptidases/genetics; Species Specificity; Streptococcus mutans/enzymology; Streptococcus mutans/genetics; Trypanosoma brucei brucei/enzymology; Trypanosoma brucei brucei/genetics
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