PMID:21831320
| Citation |
Yao, R, Hirose, Y, Sarkar, D, Nakahigashi, K, Ye, Q and Shimizu, K (2011) Catabolic regulation analysis of Escherichia coli and its crp, mlc, mgsA, pgi and ptsG mutants. Microb. Cell Fact. 10:67 |
|---|---|
| Abstract |
Most bacteria can use various compounds as carbon sources. These carbon sources can be either co-metabolized or sequentially metabolized, where the latter phenomenon typically occurs as catabolite repression. From the practical application point of view of utilizing lignocellulose for the production of biofuels etc., it is strongly desirable to ferment all sugars obtained by hydrolysis from lignocellulosic materials, where simultaneous consumption of sugars would benefit the formation of bioproducts. However, most organisms consume glucose prior to consumption of other carbon sources, and exhibit diauxic growth. It has been shown by fermentation experiments that simultaneous consumption of sugars can be attained by ptsG, mgsA mutants etc., but its mechanism has not been well understood. It is strongly desirable to understand the mechanism of metabolic regulation for catabolite regulation to improve the performance of fermentation. |
| Links |
PubMed PMC3169459 Online version:10.1186/1475-2859-10-67 |
| Keywords |
Carbon Dioxide/metabolism; Carbon Isotopes/chemistry; Carbon Isotopes/metabolism; Catabolite Repression/genetics; Citric Acid Cycle/physiology; Cyclic AMP Receptor Protein/antagonists & inhibitors; Cyclic AMP Receptor Protein/genetics; Cyclic AMP Receptor Protein/metabolism; Escherichia coli/metabolism; Escherichia coli Proteins/antagonists & inhibitors; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Fermentation; Gene Knockout Techniques; Glucose/metabolism; Glucose-6-Phosphate Isomerase/antagonists & inhibitors; Glucose-6-Phosphate Isomerase/genetics; Glucose-6-Phosphate Isomerase/metabolism; Glyoxylates/metabolism; Mutation; Phosphoenolpyruvate Sugar Phosphotransferase System/antagonists & inhibitors; Phosphoenolpyruvate Sugar Phosphotransferase System/genetics; Phosphoenolpyruvate Sugar Phosphotransferase System/metabolism; Repressor Proteins/antagonists & inhibitors; Repressor Proteins/genetics; Repressor Proteins/metabolism |
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