PMID:21830070

Citation	Kaliniene, L, Klausa, V, Zajančkauskaite, A, Nivinskas, R and Truncaite, L (2011) Genome of low-temperature T4-related bacteriophage vB_EcoM-VR7. Arch. Virol. 156:1913-6
Abstract	The complete genome sequence of the T4-related low-temperature Escherichia coli bacteriophage vB_EcoM-VR7 was determined. The genome sequence is 169,285 bp long, with a G+C content of 40.3%. Overall, 95% of the phage genome is coding. It encodes 293 putative protein-encoding open reading frames (ORFs) and tRNA(Met). More than half (59%) of the genomic DNA lacks significant homology with the DNA of T4, but once translated, 72% of the vB_EcoM-VR7 genome (211 ORFs) encodes protein homologues of T4 genes. Overall, 46 vB_EcoM-VR7 ORFs have no homologues in T4 but are derived from other T4-related phages, nine ORFs show similarities to bacterial or non-T4-related phage genes, and 27 ORFs are unique to vB_EcoM-VR7. This phage lacks several T4 enzymes involved in host DNA degradation; however, there is extensive representation of the DNA replication, recombination and repair enzymes as well as the viral capsid and tail structural genes.
Links	PubMed Online version:10.1007/s00705-011-1084-y
Keywords	Bacteriophages/classification; Bacteriophages/genetics; Bacteriophages/isolation & purification; Base Sequence; Escherichia coli/virology; Genome, Viral; Molecular Sequence Data; Open Reading Frames; Sewage/virology; Temperature; Viral Proteins/genetics
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