PMID:21693461
| Citation |
Alt, S, Mitchenall, LA, Maxwell, A and Heide, L (2011) Inhibition of DNA gyrase and DNA topoisomerase IV of Staphylococcus aureus and Escherichia coli by aminocoumarin antibiotics. J. Antimicrob. Chemother. 66:2061-9 |
|---|---|
| Abstract |
Aminocoumarin antibiotics are potent inhibitors of bacterial DNA gyrase. We investigated the inhibitory and antibacterial activity of naturally occurring aminocoumarin antibiotics and six structural analogues (novclobiocins) against DNA gyrase and DNA topoisomerase IV from Escherichia coli and Staphylococcus aureus as well as the effect of potassium and sodium glutamate on the activity of these enzymes. |
| Links |
PubMed Online version:10.1093/jac/dkr247 |
| Keywords |
Aminocoumarins/chemistry; Aminocoumarins/pharmacology; Anti-Bacterial Agents/chemistry; Anti-Bacterial Agents/pharmacology; Bacterial Proteins/biosynthesis; Bacterial Proteins/isolation & purification; Cloning, Molecular; DNA Gyrase/antagonists & inhibitors; DNA Gyrase/genetics; DNA Topoisomerase IV/antagonists & inhibitors; DNA Topoisomerase IV/genetics; DNA, Superhelical/chemistry; Escherichia coli/drug effects; Escherichia coli/enzymology; Escherichia coli/genetics; Glutamates/pharmacology; Microbial Sensitivity Tests; Reverse Transcriptase Polymerase Chain Reaction; Sodium Glutamate/pharmacology; Staphylococcus aureus/drug effects; Staphylococcus aureus/enzymology; Staphylococcus aureus/genetics; Structure-Activity Relationship; Topoisomerase Inhibitors/pharmacology |
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