PMID:2168148
| Citation |
Yoshida, H, Bogaki, M, Nakamura, M and Nakamura, S (1990) Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli. Antimicrob. Agents Chemother. 34:1271-2 |
|---|---|
| Abstract |
Nucleotide sequence analysis of the gyrA genes of 10 spontaneous quinolone-resistant gyrA mutants of Escherichia coli KL16, including four mutants examined previously, disclosed that quinolone resistance was caused by a point mutation within the region between amino acids 67 and 106, especially in the vicinity of amino acid 83, of the GyrA protein. |
| Links | |
| Keywords |
4-Quinolones; Anti-Infective Agents/pharmacology; DNA Topoisomerases, Type II/genetics; Drug Resistance, Microbial/genetics; Escherichia coli/drug effects; Escherichia coli/genetics; Mutation |
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