PMID:21595941
| Citation |
Serrano, MÁ and Sagués, F (2011) Network-based scoring system for genome-scale metabolic reconstructions. BMC Syst Biol 5:76 |
|---|---|
| Abstract |
Network reconstructions at the cell level are a major development in Systems Biology. However, we are far from fully exploiting its potentialities. Often, the incremental complexity of the pursued systems overrides experimental capabilities, or increasingly sophisticated protocols are underutilized to merely refine confidence levels of already established interactions. For metabolic networks, the currently employed confidence scoring system rates reactions discretely according to nested categories of experimental evidence or model-based likelihood. |
| Links |
PubMed PMC3113238 Online version:10.1186/1752-0509-5-76 |
| Keywords |
Computational Biology/methods; Computer Simulation; Escherichia coli/genetics; Escherichia coli Proteins/metabolism; Genes, Bacterial; Genome; Metabolic Networks and Pathways/genetics; Models, Biological; Models, Statistical; Probability; Systems Biology |
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