PMID:21541325
| Citation |
Deininger, KN, Horikawa, A, Kitko, RD, Tatsumi, R, Rosner, JL, Wachi, M and Slonczewski, JL (2011) A requirement of TolC and MDR efflux pumps for acid adaptation and GadAB induction in Escherichia coli. PLoS ONE 6:e18960 |
|---|---|
| Abstract |
The TolC outer membrane channel is a key component of several multidrug resistance (MDR) efflux pumps driven by H(+) transport in Escherichia coli. While tolC expression is under the regulation of the EvgA-Gad acid resistance regulon, the role of TolC in growth at low pH and extreme-acid survival is unknown. |
| Links |
PubMed PMC3082540 Online version:10.1371/journal.pone.0018960 |
| Keywords |
Acids/pharmacology; Adaptation, Physiological/drug effects; Bacterial Outer Membrane Proteins/metabolism; Drug Resistance, Multiple/drug effects; Enzyme Induction/drug effects; Escherichia coli K12/drug effects; Escherichia coli K12/enzymology; Escherichia coli K12/genetics; Escherichia coli K12/growth & development; Escherichia coli Proteins/biosynthesis; Escherichia coli Proteins/metabolism; Glutamate Decarboxylase/biosynthesis; Glutamates/pharmacology; Hydrogen-Ion Concentration/drug effects; Membrane Proteins/biosynthesis; Membrane Transport Proteins/metabolism; Microbial Viability/drug effects; Mutation/genetics |
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