PMID:21481254

Citation	Waegeman, H, Beauprez, J, Moens, H, Maertens, J, De Mey, M, Foulquié-Moreno, MR, Heijnen, JJ, Charlier, D and Soetaert, W (2011) Effect of iclR and arcA knockouts on biomass formation and metabolic fluxes in Escherichia coli K12 and its implications on understanding the metabolism of Escherichia coli BL21 (DE3). BMC Microbiol. 11:70
Abstract	Gene expression is regulated through a complex interplay of different transcription factors (TFs) which can enhance or inhibit gene transcription. ArcA is a global regulator that regulates genes involved in different metabolic pathways, while IclR as a local regulator, controls the transcription of the glyoxylate pathway genes of the aceBAK operon. This study investigates the physiological and metabolic consequences of arcA and iclR deletions on E. coli K12 MG1655 under glucose abundant and limiting conditions and compares the results with the metabolic characteristics of E. coli BL21 (DE3).
Links	PubMed PMC3094197 Online version:10.1186/1471-2180-11-70
Keywords	Bacterial Outer Membrane Proteins/genetics; Bacterial Outer Membrane Proteins/metabolism; Biomass; Escherichia coli K12/genetics; Escherichia coli K12/growth & development; Escherichia coli K12/metabolism; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Gene Expression Regulation, Bacterial; Gene Knockout Techniques; Metabolic Networks and Pathways/genetics; Repressor Proteins/genetics; Repressor Proteins/metabolism
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