PMID:21453489
| Citation |
Poteete, AR (2011) Recombination phenotypes of Escherichia coli greA mutants. BMC Mol. Biol. 12:12 |
|---|---|
| Abstract |
The elongation factor GreA binds to RNA polymerase and modulates transcriptional pausing. Some recent research suggests that the primary role of GreA may not be to regulate gene expression, but rather, to promote the progression of replication forks which collide with RNA polymerase, and which might otherwise collapse. Replication fork collapse is known to generate dsDNA breaks, which can be recombinogenic. It follows that GreA malfunction could have consequences affecting homologous recombination. |
| Links |
PubMed PMC3078854 Online version:10.1186/1471-2199-12-12 |
| Keywords |
Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Mutation; Phenotype; Rec A Recombinases/genetics; Rec A Recombinases/metabolism; Recombination, Genetic; Transcription Factors/genetics; Transcription Factors/metabolism |
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