PMID:21408113
| Citation |
Reyes, LH, Almario, MP and Kao, KC (2011) Genomic library screens for genes involved in n-butanol tolerance in Escherichia coli. PLoS ONE 6:e17678 |
|---|---|
| Abstract |
n-Butanol is a promising emerging biofuel, and recent metabolic engineering efforts have demonstrated the use of several microbial hosts for its production. However, most organisms have very low tolerance to n-butanol (up to 2% (v/v)), limiting the economic viability of this biofuel. The rational engineering of more robust n-butanol production hosts relies upon understanding the mechanisms involved in tolerance. However, the existing knowledge of genes involved in n-butanol tolerance is limited. The goal of this study is therefore to identify E. coli genes that are involved in n-butanol tolerance. |
| Links |
PubMed PMC3050900 Online version:10.1371/journal.pone.0017678 |
| Keywords |
1-Butanol/pharmacology; Adaptation, Physiological/drug effects; Adaptation, Physiological/genetics; Cell Membrane/drug effects; Cell Membrane/genetics; Comparative Genomic Hybridization; Escherichia coli/drug effects; Escherichia coli/genetics; Escherichia coli/growth & development; Gene Expression Profiling; Gene Knockout Techniques; Genes, Bacterial/genetics; Genetic Testing; Genomic Library; Kinetics; Molecular Sequence Annotation |
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