PMID:21392509
| Citation |
Lewis, M (2011) A tale of two repressors. J. Mol. Biol. 409:14-27 |
|---|---|
| Abstract |
Few proteins have had such a strong impact on a field, as the lac repressor and λ repressor have had in Molecular Biology in bacteria. The genes required for lactose utilization are negatively regulated; the lac repressor binds to an upstream operator blocking the transcription of the enzymes necessary for lactose utilization. A similar switch regulates the virus life cycle; λ repressor binds to an operator site and blocks transcription of the phage genes necessary for lytic development. It is now 50 years since Jacob and Monod first proposed a model for gene regulation, which survives essentially unchanged in contemporary textbooks. Jacob, F. & Monod, J. (1961). Genetic regulatory mechanisms in the synthesis of proteins. J. Mol. Biol. 3, 318-356. This model provides a cogent depiction of how a set of genes can be coordinately transcribed in response to environmental conditions and regulates metabolic events in the cell. A historical perspective that illustrates the role these two repressor molecules played and their contribution to our understanding of gene regulation is presented. |
| Links |
PubMed PMC3104267 Online version:10.1016/j.jmb.2011.02.023 |
| Keywords |
Bacteriophage lambda/genetics; DNA, Bacterial/metabolism; DNA, Viral/metabolism; Escherichia coli/genetics; Escherichia coli Proteins/metabolism; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Viral; History, 20th Century; History, 21st Century; Lac Repressors/metabolism; Molecular Biology/history; Molecular Biology/trends; Operator Regions, Genetic; Protein Binding; Repressor Proteins/metabolism; Viral Regulatory and Accessory Proteins/metabolism |
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