PMID:21350502
| Citation |
Ezraty, B, Chabalier, M, Ducret, A, Maisonneuve, E and Dukan, S (2011) CO2 exacerbates oxygen toxicity. EMBO Rep. 12:321-6 |
|---|---|
| Abstract |
Reactive oxygen species (ROS) are harmful because they can oxidize biological macromolecules. We show here that atmospheric CO(2) (concentration range studied: 40-1,000 p.p.m.) increases death rates due to H(2)O(2) stress in Escherichia coli in a dose-specific manner. This effect is correlated with an increase in H(2)O(2)-induced mutagenesis and, as shown by 8-oxo-guanine determinations in cells, DNA base oxidation rates. Moreover, the survival of mutants that are sensitive to aerobic conditions (Hpx(-) dps and recA fur), presumably because of their inability to tolerate ROS, seems to depend on CO(2) concentration. Thus, CO(2) exacerbates ROS toxicity by increasing oxidative cellular lesions. |
| Links |
PubMed PMC3077260 Online version:10.1038/embor.2011.7 |
| Keywords |
Carbon Dioxide/toxicity; Escherichia coli/drug effects; Escherichia coli/metabolism; Hydrogen Peroxide/toxicity; Mutagenesis/drug effects; Oxidation-Reduction/drug effects; Reactive Oxygen Species/metabolism |
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