PMID:21338480

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Citation

Gabbianelli, R, Scotti, R, Ammendola, S, Petrarca, P, Nicolini, L and Battistoni, A (2011) Role of ZnuABC and ZinT in Escherichia coli O157:H7 zinc acquisition and interaction with epithelial cells. BMC Microbiol. 11:36

Abstract

Zinc is an essential element for all living cells. Recent studies have shown that the ZnuABC zinc uptake system significantly contributes to the ability of several pathogens to multiply in the infected host and cause disease, suggesting that zinc is scarcely available within different tissues of the host. To better understand the role of zinc in bacterial pathogenicity, we have undertaken a functional characterization of the role of the ZnuABC-mediated zinc uptake pathway in enterohemorrhagic Escherichia coli O157:H7.

Links

PubMed PMC3053223 Online version:10.1186/1471-2180-11-36

Keywords

ATP-Binding Cassette Transporters/genetics; ATP-Binding Cassette Transporters/metabolism; Bacterial Adhesion; Caco-2 Cells; Epithelial Cells/microbiology; Escherichia coli O157/genetics; Escherichia coli O157/metabolism; Escherichia coli O157/pathogenicity; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Humans; Zinc/metabolism

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