PMID:21338412
| Citation |
Dietrich, LE and Kiley, PJ (2011) A shared mechanism of SoxR activation by redox-cycling compounds. Mol. Microbiol. 79:1119-22 |
|---|---|
| Abstract |
In this issue of Molecular Microbiology, Gu and Imlay show that a class of compounds known as redox-cycling agents directly activate the transcription factor SoxR of Escherichia coli and cause cellular toxicity independent of the production of the reactive oxygen species superoxide. Despite the fact that redox-cycling agents increase formation of superoxide in E. coli, the results described in this new publication revise the long-held assumption that superoxide is responsible for the activation of SoxR and for all of the major toxic effects of redox-cycling drugs. This study also suggests that the critical function of the SoxRS regulon in E. coli is in protection against redox-cycling agents and not exclusively the defence against superoxide. |
| Links |
PubMed Online version:10.1111/j.1365-2958.2011.07552.x |
| Keywords |
Bacterial Proteins/chemistry; Bacterial Proteins/metabolism; Escherichia coli/drug effects; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Gene Expression Regulation, Bacterial/drug effects; Methylphenazonium Methosulfate/pharmacology; Paraquat/pharmacology; Superoxides/metabolism; Trans-Activators/genetics; Trans-Activators/metabolism; Transcription Factors/chemistry; Transcription Factors/metabolism; Vitamin K 3/pharmacology |
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