PMID:21335453
| Citation |
Taniguchi, N, Suzuki, T, Berney, M, Yoshida, M and Cook, GM (2011) The regulatory C-terminal domain of subunit ε of F₀F₁ ATP synthase is dispensable for growth and survival of Escherichia coli. J. Bacteriol. 193:2046-52 |
|---|---|
| Abstract |
The C-terminal domain of subunit ε of the bacterial F₀F₁ ATP synthase is reported to be an intrinsic inhibitor of ATP synthesis/hydrolysis activity in vitro, preventing wasteful hydrolysis of ATP under low-energy conditions. Mutants defective in this regulatory domain exhibited no significant difference in growth rate, molar growth yield, membrane potential, or intracellular ATP concentration under a wide range of growth conditions and stressors compared to wild-type cells, suggesting this inhibitory domain is dispensable for growth and survival of Escherichia coli. |
| Links |
PubMed PMC3133022 Online version:10.1128/JB.01422-10 |
| Keywords |
Escherichia coli/growth & development; Escherichia coli/metabolism; Escherichia coli/physiology; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Microbial Viability; Proton-Translocating ATPases/genetics; Proton-Translocating ATPases/metabolism; Sequence Deletion |
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