PMID:2123815
| Citation |
Van Vliet, F, Crabeel, M, Boyen, A, Tricot, C, Stalon, V, Falmagne, P, Nakamura, Y, Baumberg, S and Glansdorff, N (1990) Sequences of the genes encoding argininosuccinate synthetase in Escherichia coli and Saccharomyces cerevisiae: comparison with methanogenic archaebacteria and mammals. Gene 95:99-104 |
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| Abstract |
The nucleotide (nt) sequences of the genes encoding argininosuccinate synthetase from Escherichia coli K-12 (argG) and Saccharomyces cerevisiae (ARG1) were determined. The deduced amino-acid sequences were compared to each other and to their counterparts in two methanogens and in mammals. Three regions are highly conserved. Two of them appear to contain possible Walker-type nt-binding sites [Walker et al., EMBO J. 1 (1982) 945-951] and are therefore candidates for ATP-binding sites. The third region shows some similarity to a short portion of the N-proximal part of the PurA enzyme which catalyses an analogous reaction. |
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| Keywords |
Amino Acid Sequence; Animals; Archaea/genetics; Argininosuccinate Synthase/genetics; Base Sequence; Cloning, Molecular; Escherichia coli/genetics; Genes, Bacterial; Genes, Fungal; Mammals/genetics; Molecular Sequence Data; Saccharomyces cerevisiae/genetics |
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