PMID:21151867
| Citation |
Ruhe, ZC and Hayes, CS (2010) The N-terminus of GalE induces tmRNA activity in Escherichia coli. PLoS ONE 5:e15207 |
|---|---|
| Abstract |
The tmRNA quality control system recognizes stalled translation complexes and facilitates ribosome recycling in a process termed 'ribosome rescue'. During ribosome rescue, nascent chains are tagged with the tmRNA-encoded SsrA peptide, which targets tagged proteins for degradation. In Escherichia coli, tmRNA rescues ribosomes arrested on truncated messages, as well as ribosomes that are paused during elongation and termination. |
| Links |
PubMed PMC2998420 Online version:10.1371/journal.pone.0015207 |
| Keywords |
Codon; Escherichia coli/enzymology; Escherichia coli Proteins/chemistry; Gene Deletion; Mass Spectrometry/methods; Oligonucleotides/chemistry; Open Reading Frames; Plasmids/metabolism; Protein Conformation; Protein Structure, Tertiary; RNA, Bacterial/metabolism; RNA, Messenger/metabolism; Recombinant Fusion Proteins/chemistry; Ribosomes/metabolism; Thioredoxins/chemistry; UDPglucose 4-Epimerase/chemistry; UDPglucose 4-Epimerase/metabolism |
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