PMID:21122111
| Citation |
Valgepea, K, Adamberg, K, Nahku, R, Lahtvee, PJ, Arike, L and Vilu, R (2010) Systems biology approach reveals that overflow metabolism of acetate in Escherichia coli is triggered by carbon catabolite repression of acetyl-CoA synthetase. BMC Syst Biol 4:166 |
|---|---|
| Abstract |
The biotechnology industry has extensively exploited Escherichia coli for producing recombinant proteins, biofuels etc. However, high growth rate aerobic E. coli cultivations are accompanied by acetate excretion i.e. overflow metabolism which is harmful as it inhibits growth, diverts valuable carbon from biomass formation and is detrimental for target product synthesis. Although overflow metabolism has been studied for decades, its regulation mechanisms still remain unclear. |
| Links |
PubMed PMC3014970 Online version:10.1186/1752-0509-4-166 |
| Keywords |
Acetate-CoA Ligase/genetics; Acetate-CoA Ligase/metabolism; Acetates/metabolism; Carbon/metabolism; Down-Regulation; Escherichia coli/enzymology; Escherichia coli/genetics; Escherichia coli/growth & development; Escherichia coli/metabolism; Gene Expression Profiling; Kinetics; Models, Biological; Phosphate Acetyltransferase/metabolism; Proteomics; Systems Biology/methods |
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