PMID:21045542
| Citation |
Rabhi, M, Tuma, R and Boudvillain, M RNA remodeling by hexameric RNA helicases. RNA Biol 7:655-66 |
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| Abstract |
The unwinding of RNA helices and the disruption of RNA-protein complexes are critical steps of cellular metabolism that are carried out by ubiquitous NTP-dependent enzymes named RNA helicases. Here, we review the structures, mechanisms, and biochemical properties of two RNA helicases known to adopt a homo-hexameric ring architecture: the P4 packaging motor of bacteriophage φ8, a Super-Family 4 helicase, and Escherichia coli's transcription termination factor Rho from the Super-Family 5 of helicases. We emphasize the many similarities as well as key differences that characterize the Rho and P4 motor mechanisms and highlight important questions that remain to be addressed. |
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| Keywords |
Bacteriophages/enzymology; Endodeoxyribonucleases/chemistry; Endodeoxyribonucleases/metabolism; Escherichia coli/enzymology; Nucleotides/metabolism; RNA/chemistry; RNA/metabolism; RNA Helicases/chemistry; RNA Helicases/metabolism; Substrate Specificity; rho-Associated Kinases/chemistry; rho-Associated Kinases/metabolism |
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