PMID:20639340
| Citation |
Chubiz, LM and Rao, CV (2010) Aromatic acid metabolites of Escherichia coli K-12 can induce the marRAB operon. J. Bacteriol. 192:4786-9 |
|---|---|
| Abstract |
MarR is a key regulator of the marRAB operon involved in antibiotic resistance and solvent stress tolerance in Escherichia coli. We show that two metabolic intermediates, 2,3-dihydroxybenzoate and anthranilate, involved in enterobactin and tryptophan biosynthesis, respectively, can activate marRAB transcription. We also found that a third intermediate involved in ubiquinone biosynthesis, 4-hydroxybenzoate, activates marRAB transcription in the absence of TolC. Of the three, however, only 2,3-dihydroxybenzoate directly binds MarR and affects its activity. |
| Links |
PubMed PMC2937402 Online version:10.1128/JB.00371-10 |
| Keywords |
Bacterial Outer Membrane Proteins/genetics; Bacterial Proteins/genetics; DNA-Binding Proteins/genetics; Escherichia coli/drug effects; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins/genetics; Gene Expression Regulation, Bacterial; Hydroxybenzoates/pharmacology; Membrane Transport Proteins/genetics; Operon/drug effects; Operon/genetics; Parabens/pharmacology; Promoter Regions, Genetic/drug effects; Promoter Regions, Genetic/genetics; Protein Binding/drug effects; Protein Binding/genetics; Repressor Proteins/genetics; ortho-Aminobenzoates/pharmacology |
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