PMID:20639336

Citation	Frisch, RL, Su, Y, Thornton, PC, Gibson, JL, Rosenberg, SM and Hastings, PJ (2010) Separate DNA Pol II- and Pol IV-dependent pathways of stress-induced mutation during double-strand-break repair in Escherichia coli are controlled by RpoS. J. Bacteriol. 192:4694-700
Abstract	Previous work showed that about 85% of stress-induced mutations associated with DNA double-strand break repair in carbon-starved Escherichia coli result from error-prone DNA polymerase IV (Pol IV) (DinB) and that the mutagenesis is controlled by the RpoS stress response, which upregulates dinB. We report that the remaining mutagenesis requires high-fidelity Pol II, and that this component also requires RpoS. The results identify a second DNA polymerase contributing to stress-induced mutagenesis and show that RpoS promotes mutagenesis by more than the simple upregulation of dinB.
Links	PubMed PMC2937414 Online version:10.1128/JB.00570-10
Keywords	Bacterial Proteins/genetics; Bacterial Proteins/metabolism; DNA Polymerase II/genetics; DNA Polymerase II/metabolism; DNA Polymerase beta/genetics; DNA Polymerase beta/metabolism; DNA Repair/genetics; Escherichia coli/enzymology; Escherichia coli/genetics; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Mutagenesis; Mutation/genetics; Sigma Factor/genetics; Sigma Factor/metabolism; Signal Transduction/genetics; Signal Transduction/physiology
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