PMID:2043108
| Citation |
Persson, B, Jeffery, J and Jörnvall, H (1991) Different segment similarities in long-chain dehydrogenases. Biochem. Biophys. Res. Commun. 177:218-23 |
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| Abstract |
Long-chain dehydrogenases were scrutinized for common patterns. Overall molecular similarities are not discerned, in contrast to the situation for several short-chain and medium-chain dehydrogenases, but coenzyme-binding segments are discernible. Species variants of glucose-6-phosphate dehydrogenase reveal about 20% strictly conserved residues, grouped into three segments and supporting assignments of sites for coenzyme-binding and catalysis. Glycine is overrepresented among the residues conserved, typical of distantly related proteins. Two of the enzymes within the pentose phosphate pathway reveal a distant similarity of interest for further evaluation, between a C-terminal 178-residue segment of glucose-6-phosphate dehydrogenase and the N-terminal part of 6-phosphogluconate dehydrogenase. |
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| Keywords |
Amino Acid Sequence; Binding Sites; Coenzymes/metabolism; Databases, Factual; Escherichia coli/enzymology; Humans; Molecular Sequence Data; Oxidoreductases/genetics; Oxidoreductases/metabolism; Protein Conformation; Rhodobacter capsulatus/enzymology; Sequence Homology, Nucleic Acid |
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