PMID:20308588

Citation	Fischer-Friedrich, E, Meacci, G, Lutkenhaus, J, Chaté, H and Kruse, K (2010) Intra- and intercellular fluctuations in Min-protein dynamics decrease with cell length. Proc. Natl. Acad. Sci. U.S.A. 107:6134-9
Abstract	Self-organization of proteins in space and time is of crucial importance for the functioning of cellular processes. Often, this organization takes place in the presence of strong random fluctuations due to the small number of molecules involved. We report on stochastic switching of the Min-protein distributions between the two cell halves in short Escherichia coli cells. A computational model provides strong evidence that the macroscopic switching is rooted in microscopic noise on the molecular scale. In longer bacteria, the switching turns into regular oscillations that are required for positioning of the division plane. As the pattern becomes more regular, cell-to-cell variability also lessens, indicating cell length-dependent regulation of Min-protein activity.
Links	PubMed PMC2851992 Online version:10.1073/pnas.0911708107
Keywords	Adenosine Triphosphatases/genetics; Adenosine Triphosphatases/metabolism; Adenosine Triphosphate/metabolism; Cell Cycle Proteins/genetics; Cell Cycle Proteins/metabolism; Escherichia coli/cytology; Escherichia coli/metabolism; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Protein Binding; Protein Transport; Stochastic Processes
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