PMID:20223989
| Citation |
Shinar, G and Feinberg, M (2010) Structural sources of robustness in biochemical reaction networks. Science 327:1389-91 |
|---|---|
| Abstract |
In vivo variations in the concentrations of biomolecular species are inevitable. These variations in turn propagate along networks of chemical reactions and modify the concentrations of still other species, which influence biological activity. Because excessive variations in the amounts of certain active species might hamper cell function, regulation systems have evolved that act to maintain concentrations within tight bounds. We identify simple yet subtle structural attributes that impart concentration robustness to any mass-action network possessing them. We thereby describe a large class of robustness-inducing networks that already embraces two quite different biochemical modules for which concentration robustness has been observed experimentally: the Escherichia coli osmoregulation system EnvZ-OmpR and the glyoxylate bypass control system isocitrate dehydrogenase kinase-phosphatase-isocitrate dehydrogenase. The structural attributes identified here might confer robustness far more broadly. |
| Links |
PubMed Online version:10.1126/science.1183372 |
| Keywords |
Bacterial Outer Membrane Proteins/metabolism; Bacterial Proteins/metabolism; Escherichia coli/metabolism; Escherichia coli Proteins/metabolism; Glyoxylates/metabolism; Isocitrate Dehydrogenase/metabolism; Metabolic Networks and Pathways; Models, Biological; Models, Chemical; Multienzyme Complexes/metabolism; Osmolar Concentration; Phosphorylation; Signal Transduction; Trans-Activators/metabolism |
| edit table |
Significance
You can help EcoliWiki by summarizing why this paper is useful
Useful Materials and Methods
You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.
Annotations
<annotationlinks/>
EcoliWiki Links
Add links to pages that link here (e.g. gene, product, method pages)
See also
References
See Help:References for how to manage references in EcoliWiki.