PMID:19935661
| Citation |
Werner, AK, Romeis, T and Witte, CP (2010) Ureide catabolism in Arabidopsis thaliana and Escherichia coli. Nat. Chem. Biol. 6:19-21 |
|---|---|
| Abstract |
The availability of whole genome sequences boosts the identification of biochemical pathways conserved across species using tools of comparative genomics. A cross-organism protein association analysis allowed us to identify two enzymes, ureidoglycine aminohydrolase and ureidoglycolate amidohydrolase, that catalyze the final reactions of purine degradation in the model plant Arabidopsis thaliana. A similar pathway was found in Escherichia coli, while an alternative metabolic route via ureidoglycine transaminase can be predicted for other organisms. |
| Links |
PubMed Online version:10.1038/nchembio.265 |
| Keywords |
Allantoin/chemistry; Amidine-Lyases/chemistry; Aminohydrolases/chemistry; Arabidopsis/metabolism; Arabidopsis Proteins/chemistry; Catalysis; Databases, Protein; Escherichia coli/metabolism; Genomics; Lyases/chemistry; Magnetic Resonance Spectroscopy; Models, Biological; Nitrogen/chemistry; Proteomics/methods; Software; Species Specificity |
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