PMID:19914241
| Citation |
Hayes, CS and Keiler, KC (2010) Beyond ribosome rescue: tmRNA and co-translational processes. FEBS Lett. 584:413-9 |
|---|---|
| Abstract |
tmRNA is a unique bi-functional RNA that acts as both a tRNA and an mRNA to enter stalled ribosomes and direct the addition of a peptide tag to the C terminus of nascent polypeptides. Despite a reasonably clear understanding of tmRNA activity, the reason for its absolute conservation throughout the eubacteria is unknown. Although tmRNA plays many physiological roles in different bacterial systems, recent studies suggest a general role for trans-translation in monitoring protein folding and perhaps other co-translational processes. This review will focus on these new hypotheses and the data that support them. |
| Links |
PubMed PMC2794900 Online version:10.1016/j.febslet.2009.11.023 |
| Keywords |
Bacteria/metabolism; Protein Biosynthesis; Protein Folding; RNA, Bacterial/physiology; Ribosomes/metabolism |
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